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19 June 2009..
tamat sudah industrial attachment kami di sini..

fyi..kilang ni adalah tOkey appetOn..=)

kt cni..me n jijah were attached at R&D Department..
on our 1st day of internship..trus kne jOin meeting diOrg..
fuhh..semput nafas bile bigbOs secare tibe2 suh kitOrg intrOduce diri dlm meeting tuu..

n part xleh blah bile die tnye..

"are yOu really interested in industry??"

errr..kelu..nk ckp minat..xde la minat sgt..nk ckp x minat..kOt bg bad impressiOn kt die..plus..wt attachment kt cni..klu rs industry best x slah klu nk jOin industry..hehee..kOnon ajee..

then..we were assigned to 2 supervisOrs..Pharmaceutical fOrmulatiOn scientist..Mr SOnny and Miss Yulia..bOth are nice and help us a lOt..Thanks guys~

then..we were asked tO undertake SOnny's prOject which is Axcel Ciprofloxacin tab as to be cOmpleted during our attchement.erkk..terkujat pOn ade tp buat2 cOol..It was unexpected because our previOus seniOrs kne buat PCM..but we all kne buat antibiOtic which is film-cOated tab..in directly..we used tO learn abOut cOating tOo..huhh..

Benchmarked of Our product..CiprObay..ape yg kami kne buat ialah kne cari fOrmulation, decide manufacturing process cane yg kami nk buat.sOunds like simple je but there are lots of 'xtahu nk buat cane' wOrks tO be dOne..but we did learn..step by step..



Hasil trial batch kami..kami sempat buat 3 trial batches je but da cukup memenatkan sbb nk kne tunggu pilOt plant free..



ye laa..fOrmulators lain pOn nk buat prOduct diOrg gak, sooo akn ade jdual la sape yg akn masuk PilOt Plant. b4 buat trials ni..kami kne cari seniri raw materials..trace seniri dr sms or existing..klu x ckup kne order..da ade kne g buat assay dulu.test raw materials ni bOley gune ke x..blaja plak gune HPLC.selame ni kt uia..kite asyk buat dilution seniri je pstu abg2 n akak2 lab yg tlg buat test run utk kite.pstu kite dOk tgu diorg print result je.tp kt cni..x psl kne buat mObile phase seniri..blaja setting equipment tu seniri..huuuu..smpai mlm kami keje..ari sabtu pOn dtg lg..Owhh lupe..b4 tu kne cari seniri ape Analytical Protocol yg kte nk ikut utk buat test tu.berpusing pusing cari nk ikut yg mane..kang salah pilih..kitOrg fOllow methOds yg susah or mybe materials tu x wujud kt R&D. prOblems la plak..AP tu ecly depend kte nk ikut pharmacopoeia mane.alhamdulillah..dgn ade nye analyst2 R&D yg baik hati..kitOrg berjaye gak buat sume test2 utk product ni..terima kasih sume! (^_^)

1st Trial kitOrg..tablet sticking yg mane x ckup lubricant i.e mg stearate..soo..utk next trial..kitOrg tmbh la mg stearate ni

2nd trial..sbb salah timing jdual..kitOrg lmbt msuk pilot plant utk tabletting but mg stearate da msuk awal2 which lead to affect the hardness of the tablet..

3rd trial kitOrg wt scale up skit dgn buat 1kg.b4 ni asyk buat 300g je sbb API x ckup.sO kunun nk save API.last2 bOley request dr stOre.trus buat scale up so that we can prOceed with cOating process..

Our product --> Axcel Ciprofloxacin 500mg tablet..da siap cOating..redi utk FP test..


mase nk sieve cipro ni..Allah je tau betape pahitnye ubat ni..huii...mmg dasat ah..da pkai mask 2 lapis pOn rase lg..

utk 1st trial..kami just buat ikut hand manufacturing je.all..yg mcm kite buat time industrial punye lab tu.mixing sume ikut dlm plstic.pastu granulatiOn pOn buat dlm stainless steel bOw je..time buat ni terigt plak dOh2 lembik yg penah kite buat time lab pstu xleh nk sieve pastu buang je.sOo..kt cni..kami blaja byk mane nk bajet sOlvent utk buat wet granulation..knape pilih wet granulation..knape gune water??knape x guna IPA??knape lame ni nk granules??knape nk kne keringkan byk ni??knape nk kne sieve smpai size gni??knape macam tu..knape macam ni..sume nk kne blaja n tau..i'm grateful tO be here..

paling hectic nk kne pasang seniri punches n dies.kt mesin ni penah ade staf yg terkepit tgn n Oh my God..mmg penah ade jari putus kt ctu..dah la kitorg nk buat caplet which is tablet yg dlm btk capsule soo..shape utk dies n punches tu kne msuk btul2 b4 tabletting..klu x nnti patah punches tu.klu sape2 yg suke kate si jijah ni malas nk buat keje time lab.kOrg mmg silap ahh..sure terbuntang mate kOrg tgk jijah psg mesin ni..pastu g angkut n bsuh sume equipment dlm pilot plant ni.x tgk lg.kegigihan jijah sieve sume pOwder ni..

Thank Allah sbb tabletting machine kt R&D gune 8 punches je.klu berpuluh cam kt production, maunyer sehari utk kitOrg psg..

Sbb pilot plant ni dlm production area..soo evritime nk buat trial batch or test..kitOrg pOn kne pakai baju angkasawan tu.sOO..ade peluang la nk ronggeng2 kt kwsn prOduction tu..

sOme of the physical tests that we need to do are thickness, hardness and uniformity of weight test.all of these tests were dOne in IPQC rOom lOcated in the prOduction area.we also did the disintegratiOn test and friability test there. in final, we test the assay fOr the product.what makes us happier is that we passed the test.for bOth assay and dissOlution test...waaa..sgt hepi..sbb KAMI HANYA AMATUR..& ape yg kami buat berjaya..mesti la kami happy \(^_^)/

kt R&D ni..we were lucky sbb diOrg freely bg kitOrg utilized sume facilities yg ade..dr internet kpd printer..telepOn..bak kate..Korg mmg akn di beri chance utk benar2 jd fOrmulatOr kt ctu.silap haribulan..kOrg kne call supplier mtk COA utk materials kOrg..hehee..yg mane kitOrg x buat :P kOrg jugak bebas utk berlegar dlm QC lab tp kt cni x best skit nk lepak.knape?? let it be our secret..heee..

dgn Yulia Puspitasari..die nmpak enjOy giler buat keje R&D ni.kalu kOrg tgk care die keje..sure 100% rase nk keje kt industry..hee..

Dgn k MAziah..Matthew Abraham and Sonny..sumenye baik2..

Kat meja kerja..(^_^)/ penyalahgunaan internet slalu terjadi di PC R&D 13 ni..heee..



abiskan mase kt cni..kami bkn aje blaja psl industrial pharmacy..tp byk gak bende len yg kami blaja..
hOw to deal with peOple..
hOw to cOmmunicate with cOlleagues..yg pastinye lebih tua dr kite..
hOw tO respect others..
hOw tO wOrk with creature name Human being..
hOw to appreciate others
hOw to make gOod decisiOn and tOlerate with others' decisiOn
blaja utk tepati mase..
blaja utk tahu mane gy penting n mane yg x penting..
blaja utk JGN BERTANGGUH..
blaja utk be nice n treat peOple nicely...

sOoo many things laaa..time ni rase mcm nk blaja je..xnk keje..tp we did knOw it wOn't happen..len la kalu kamu nk smbg mater..phd n smbg blaja je keje kamu..heee...

special appreciatiOn to my rumete..FIZA..MIDA spnj pOsting kt cni..
thanks a lOt to jijah sbb snggup susah pyh ngn kite spnjg kt R&D ni..
Sorry klu byk susahkn kOrg...

kpd syafiQ yusOf ats pertOlongan kiriman pen utk staf..hehee..jgn marah ye tulis kt blOg ni :)

& kpd seniOrs2 yg byk tlg spnjg pOsting..

nOt to left sume R&D Team Kotra Pharma..

I MISS YOU ALL~~

pesanan: utk juniOr2 yg nak amik industrial attachment..prepare urself..physically & mentally..but i'm sure..u'll be happy and mesmerized with ur jOb once u finished it..

Comments

Anonymous said…
anae....sedey plak bace mende2 ni...tringat memory di kotra~~~ahahah..tp yg pasti posting di KOTRA mmg best!!

kite pon nk byk2 ckp tenQ kt anae..sbb byk tol ilang sabar time nk wat AXCEL CIPROFLOXACIN 500mg tab ni (name penuh siap =P) ..start dr process bertulis smpai la prcticalnye smpai le nk ksk adiah kt staff..;)

tenQ sbb byk tolong kiter n slalu sbar ngn kiter ni hehe

ish ayat cm nk berpisah je hehe..
Anonymous said…
eh jap..trtggal ayat =P

"kite pon nk byk2 ckp tenQ kt anae.,sbb saba ngn kiter..hehe..sbb kite ni byk tol...."

hahhah...sile smbung dgn ayat seterusnye seperti komen diatas..tenQ =P
aNeA_hAyATi said…
hehee..klaka je..same la..kite pOn byk gak susahkan org di ats time buat cipro tu.sOri klu kite byk sOngeh gak time tu..anyway..dah rindu mR gan ke ni..??hahaa..

mmg xley lupe lgsg excushe me die tu..hahaha..Oppss..kite x g mtk maap ngn die ni..hee
ila ni said…
anea, nok ubat eczema....

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